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"Revolutionizing Early Phase Trials of New Drugs for Mood and Anxiety Spectrum Disorders: FAST-MAS"

Thursday June 13, 2013

Time: 12:00 PM to 1:00 PM
Location: Duke North, Room 2002
Directions: Get Map

Speaker/Presenter: Andrew Krystal, MD

Series: Grand Rounds

Description: Dr Andrew Krystal, MD, Professor, Psychiatry Department of Psychiatry and Behavioral Sciences Research Interests: My research is focused on better understanding the pathophysiology of sleep disorders and mood disorders and developing improved treatments for these conditions. My primary research tools are: electroencepahlography (EEG), polysomnography (PSG), computer signal analysis and modeling, functional magnetic resonance imaging (fMRI), and positron emission tomograophy (PET). Nearly all of my projects have been carried out with humans; however, projects are ongoing with gene knock-out models in mice, and lemurs in collaboration with the Duke Primate Center. A few representative current studies are: 1) Defining physiologic (EEG, PSG, PET, fMRI) correlates of sleep complaints and subtyping insomnia on the basis of the associated pathophysiology, 2) Studying the relationship of EEG data recorded during non-REM sleep, daytime function, and insomnia treatment response, 3) Developing new pharmacologic and non-pharmacologic treatments for insomnia, 4) Studying the relationship of natural sleep and hibernation-like phenomena (torpor), 5) Predicting depression treatment response on the basis of pre-treatment EEG and structural MRI data.

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